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CGP 20712 A
CAS No. 105737-62-0
CGP 20712 A( —— )
Catalog No. M32841 CAS No. 105737-62-0
CGP 20712 A (CGP 20712 mesylate) is a selective and potent β1-adrenergic receptor antagonist (IC50: 0.7 nM) with antihypertensive activity, capable of reversing RKT-induced gastric relaxation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 149 | Get Quote |
|
| 5MG | 275 | Get Quote |
|
| 10MG | 407 | Get Quote |
|
| 25MG | 642 | Get Quote |
|
| 50MG | 891 | Get Quote |
|
| 100MG | 1152 | Get Quote |
|
| 200MG | 1584 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCGP 20712 A
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NoteResearch use only, not for human use.
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Brief DescriptionCGP 20712 A (CGP 20712 mesylate) is a selective and potent β1-adrenergic receptor antagonist (IC50: 0.7 nM) with antihypertensive activity, capable of reversing RKT-induced gastric relaxation.
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DescriptionCGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors.
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In VitroIn myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors.
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In VivoPretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection.
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Synonyms——
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PathwayGPCR/G Protein
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TargetAdrenergic Receptor
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RecptorAdrenergic Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number105737-62-0
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Formula Weight590.57
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Molecular FormulaC24H29F3N4O8S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (169.33 mM; Ultrasonic )
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SMILESO=C(N)C1=CC(OCCNCC(O)COC=2C=CC(=CC2)C3=NC(=CN3C)C(F)(F)F)=CC=C1O.O=S(=O)(O)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dooley DJ, et al. CGP 20712 A: a useful tool for quantitating beta 1- and beta 2-adrenoceptors. Eur J Pharmacol. 1986 Oct 14;130(1-2):137-9.?
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